The number of studies and publications do not always correspond (e.g., a publication may include several studies or one study may be explained in several publications).
Barton A, Basham M, Foy C, Buckingham K, Somerville M. The Watcombe Housing Study: the short term effect of improving housing conditions on the health of residents. Journal of Epidemiology and Community Health 2007;61(9):771-7.
Brown MD, Reeves MJ, Meyerson K, Korzeniewski SJ. Randomized trial of a comprehensive asthma education program after an emergency department visit. Annals of Allergy, Asthma, & Immunology 2006;97(1):44-51.
Carter MC, Perzanowski M, Raymond A, Platts-Mills T. Home intervention in the treatment of asthma among inner-city children. The Journal of Allergy and Clinical Immunology 2001;108(5):732-7.
Eggleston PA, Butz A, Rand C, Curtin-Brosnan J, Kanchanaraksa S, Swartz L, et al. Home environmental intervention in inner-city asthma: a randomized controlled clinical trial. Annals of Allergy, Asthma, & Immunology 2005;95(6):518-24.
Evans III R, Gergen PJ, Mitchell H, Kattan M, Kercsmar C, Crain E, et al. A randomized clinical trial to reduce asthma morbidity among inner-city children: results of the National Cooperative Inner-City Asthma Study. The Journal of Pediatrics 1999;135(3):332-8.
Hasan RA, Zureikat GY, Camp J, Duff J, Nolan BM. The positive impact of a disease management program on asthma morbidity in inner-city children. Pediatric Asthma, Allergy & Immunology 2003;16(3):147-53.
Hughes DM, McLeod M, Garner B, Goldbloom RB. Controlled trial of a home and ambulatory program for asthmatic children. Pediatrics 1991;87(1):54-61.
Kercsmar CM, Dearborn DG, Schluchter M, Xue L, Kirchner HL, Sobolewski J, et al. Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Environmental Health Perspectives 2006;114 (10):1574-80.
Klinnert MD, Liu AH, Pearson MR, Ellison MC, Budhiraja N, Robinson JL. Short-term impact of a randomized multifaceted intervention for wheezing infants in low-income families. Archives of Pediatrics & Adolescent Medicine 2005;159:75-82.
Krieger J, Takaro TK, Song L, Beaudet N, Edwards K. A randomized controlled trial of asthma self-management support comparing clinic-based nurses and in-home community health workers: the Seattle-King County Healthy Homes II Project. Archives of Pediatrics & Adolescent Medicine 2009;163(2):141-9.
Krieger JW, Takaro T, Song L, Weaver M. The Seattle-King County Healthy Homes Project: a randomized, controlled trial of a community health worker intervention to decrease exposure to indoor asthma triggers. American Journal of Public Health 2005;95(4):652-9.
Levy JI, Brugge D, Peters JL, Clougherty JE, Saddler SS. A community-based participatory research study of multifaceted in-home environmental interventions for pediatric asthmatics in public housing. Social Science & Medicine 2006; 63(8):2191-203.
Morgan WJ, Crain EF, Gruchalla RS, O'Connor GT, Kattan M, Evans III R, et al. Results of a home-based environmental intervention among urban children with asthma [see comment]. New England Journal of Medicine 2004;351(11):1068-80.
Nicholas S, Hutchinson VE, Ortiz B, Klihr-Beall S, Jean-Louis B. Reducing childhood asthma through community-based service delivery--New York City, 2001-2004. Morbidity and Mortality Weekly Report 2005;54(1):11-4.
Nishioka K, Saito A, Akiyama K, Yasueda H. Effect of home environment control on children with atopic or non-atopic asthma. Allergology International 2006;55(2):141-8.
Oatman L. Reducing environmental triggers of asthma in homes of Minnesota children (Evaluation report: not published). Minnesota Department of Health; St. Paul (MN):2007.
Parker EA, Israel BA, Robins TG, Mentz G, Xihong L, Brakefield-Caldwell W, et al. Evaluation of community action against asthma: a community health worker intervention to improve children's asthma-related health by reducing household environmental triggers for asthma.Health Education & Behavior 2008; 35(3):376-395.
Primomo J, Johnston S, DiBiase F, Nodolf J, Noren L. Evaluation of a community-based outreach worker program for children with asthma [References]. Public Health Nursing 2006;23(3):234-41.
Shelledy DC, McCormick SR, LeGrand TS, Cardenas J, Peters JI. The effect of a pediatric asthma management program provided by respiratory therapists on patient outcomes and cost. Heart & Lung 2005;34(6):423-8.
Somerville M, Mackenzie I, Owen P, Miles D. Housing and health: does installing heating in their homes improve the health of children with asthma? Public Health 2000;114(6):434-9.
Stout JW, White LC, Rogers LT, McRorie T, Morray B. The Asthma Outreach Project: a promising approach to comprehensive asthma management. The Journal of Asthma 1998;35(1):119-27.
Thyne SM, Rising JP, Legion V, Love MB. The 'Yes We Can' Urban Asthma Partnership: a medical/social model for childhood asthma management. Journal of Asthma 2006;43(9):667-73.
Barton A, Basham M, Foy C, Buckingham K, Somerville M, on behalf of the Torbay Healthy Housing Group. The Watcombe Housing Study: the short term effect of improving housing conditions on the health of residents. J Epidemiol Community Health 2007;61(9):771–7.
Bryant-Stephens T, Li Y. Outcomes of a home-based environmental remediation for urban children with asthma. J Natl Med Assoc 2008;100(3):306–16.
Eggleston PA. Home environmental intervention in inner-city asthma: a randomized controlled clinical trial. Ann Allergy Asthma Immunol 2005;95(6):518–24.
Jowers JR, Schwartz AL, Tinkelman DG, et al. Disease management program improves asthma outcomes. Am J Manage Care 2000;6(5): 585–92.
Kattan M, Stearns SC, Crain EF, et al. Cost-effectiveness of a home-based environmental intervention for inner-city children with asthma. J Allergy Clin Imunol 2005;116(5):1058–63.
Kercsmar CM, Dearborn DG, Schluchter M, et al. Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Environ Health Perspect 2006;114(10):1574–80.
Krieger JW, Takaro TK, Song L, Weaver M. The Seattle–King County Healthy Homes Project: a randomized, controlled trial of a community health worker intervention to decrease exposure to indoor asthma triggers. Am J Public Health 2005;95(4):652–9.
Lin S, Gomez MI, Hwang SA, Franko EM, Bobier JK. An evaluation of the asthma intervention of the New York State Healthy Neighborhoods Program. J Asthma 2004;41(5):583–95.
Oatman L. Reducing environmental triggers of asthma in homes of Minnesota children. St. Paul MN: Minnesota Department of Health, 2007.
Primomo J, Johnston S, DiBiase F, Nodolf J, Noren L. Evaluation of a community-based outreach worker program for children with asthma. Public Health Nurs 2006;23(3):234–41.
Shelledy DC. The effect of a pediatric asthma management program provided by respiratory therapists on patient outcomes and cost. Heart Lung 2005;34(6):423–8.
Somerville M, Mackenzie I, Owen P, Miles D. Housing and health: does installing heating in their homes improve the health of children with asthma? Public Health 2000;114(6):434–9.
Sullivan SD, Weiss KB, Lynn H, et al. The cost-effectiveness of an inner-city asthma intervention for children. J Allergy Clin Immunol 2002;110(4):576–81.
The following outlines the search strategy for home-based multi-trigger, multicomponent environmental interventions for adults and for children and adolescents.
With the assistance of a CDC librarian, the team searched for published studies in the following databases: MEDLINE, Cochrane Library, CINAHL, PsychINFO, Web of Science, EMBASE, ERIC, and Sociological Abstracts. The team also searched bibliographic reference lists and accepted suggestions of studies from members of the team.
The team considered studies for inclusion if they:
- Were primary research published in a journal or a technical or government report
- Were published in English
- Met minimum research quality criteria for study design and execution—specifically, using designs with before-and-after comparisons in the intervention group at least or comparisons across two groups receiving different levels of intervention
- Were community-based
- Evaluated one of nine identified asthma interventions
- Addressed secondary or tertiary prevention
Studies for home-based environmental interventions were considered if they also:
- Included at least one home visit
- Were multicomponent
- Were multi-trigger
- Evaluated one or more outcomes of interest
The team searched for and accepted for possible inclusion studies published from 1966 to February 2008.
Search Terms (Medline)
Database: MEDLINE (OVID) 722 results
Note: Search was the same for the other databases with the exception of terminology (such as use of exp, and Boolean terms) which was adapted according to database requirements.
- (exp asthma/ or asthma.mp)
- exp Bronchial Hyperreactivity/mo, nu, pc, ec, ep, th
- *Respiratory sounds/nu, pc, ep, th
- (wheeze or reactive airway$).mp.
Home Interventions to Reduce Environmental Triggers
- (trigger and (reduce or reduction$)).mp. [mp=title, original title, abstract, name of substance word, subject heading word]
- exp dust/ or exp allergens/
- (reduce or reduction$).mp. [mp=title, original title, abstract, name of substance word, subject heading word]
- 7 and 8
- 6 or 9
- exp air pollution, indoor/lj, ec, pc, sn or *dust mites/
- allergen level$.mp.
- exp Patient Education/ or exp Health Education/mt, ec, og, ed, st, sn, lj, ut or exp "Patient Acceptance of Health Care"/sn
- exp Environmental Remediation/ae, an, lj, ec, mt, st
- exp intervention studies/
- 14 or 15
- 16 and 17
- environmental control.mp.
- exp Inhalation exposure/
- exposure reduction$.mp.
- 10 or 11 or 12 or 13 or 18 or 19 or 20 or 21
- 5 and 9
- 5 and 10
- 23 or 24
- Randomized Controlled Trials/ or randomized trial$.mp. or program$.mp.
- controlled trial$.mp.
- impact$.mp. or exp Sickness Impact Profile/
- study effectiveness.mp.
- effectiveness of study.mp.
- effectiveness of stud$.mp.
- exp Program Evaluation/ or evaluation$.ab.
- trial$.mp. or "Randomized Controlled Trial [Publication Type]"/
- case report$.mp. or exp "Case Reports [Publication Type]"/
- comment$.mp. or exp "Comment [Publication Type]"/
- letter$.mp. or exp "Letter [Publication Type]"/
- newspaper article$.mp. or exp "Newspaper Article [Publication Type]"/
- news.mp. or exp "News [Publication Type]"/
- drug approval/ or drug evaluation/ or neurotic disorders/ or antibodies, monoclonal/ or randomized controlled trials/ or "United States Food and Drug Administration"/ or research design/ or clinical trials/
- drug$ trial$.mp. or placebos/
Asthma and included study designs/evaluations
- 5 and 34
Asthma + Home Interventions
- 5 and 25
Asthma + Home Interventions
Asthma + any of the above interventions or study designs-excluded study designs
The economic review team adjusted the search strategy used in the effectiveness review by adding keywords specifıc to economic evaluation, such as economic(s), cost, benefıt, cost–benefıt, benefıt–cost, utility, cost–utility, QALY, cost effectiveness, and effıciency. In addition to the databases searched in the effectiveness review (i.e., MEDLINE, EMBASE, ERIC, PsycINFO, Web of Science, Cochrane Library, Sociological Abstracts, and CINAHL), social science databases such as EconLit, Social Sciences Citations Index, and JSTOR; databases of the Centre for Reviews and Dissemination at the University of York; and Google were also used. These searches were conducted for 1950 through July 2008.